Endocrine Abstracts

Case: A 52-year-old gentleman was admitted with dizziness and collapse. Past medical history revealed dyslipidemia treated with statin. Physical examination was unremarkable. Initial investigations were consistent with SIADH (sodium: 109 mmol/l, serum osmolality: 243 mOsm/kg, urine Na: 59 mmol/l and urine osmolality: 191 mOsm/kg). Urea, creatinine and random glucose were normal. CT Head showed pituitary enlargement with sellar expansion. Pituitary profile showed high prolactin...

Introduction: Women with polycystic ovary syndrome (PCOS) have a clustering of cardiovascular risk factors, such as obesity, lipid abnormalities, impaired glucose tolerance, insulin resistance and hypertension. Exercise is reported to lower cardiovascular morbidity and mortality and improve reproductive health. The effect of exercise on plasma adiponectin and the components of leptin system, namely plasma free (FL) and bound (BL) leptin concentrations, have not been previously...

Introduction: Hirsutism, the presence of terminal (coarse) hairs that appear in a male-like pattern, affects 5–10% of women and may cause concern for an underlying endocrine disorder or malignancy. Spironolactone compete for the androgen receptor in the hair follicle, therefore, it is frequently used in treatment of hirsutism. We report a case, in which treatment of hirsutism with Spironolactone interfered with androstenedione immunoassay and raised unnecessary concern ab...

Introduction: Adrenaleukodystrophy is an X linked disorder associated with functional defect of very long fatty acid (VLFCA) oxidation leading to accumulation of VLFCA in the white matter of brain and adrenal cortex. It usually presents with adrenal insufficiency and neurological problems and has association with other autoimmune conditions reported so far including vitiligo, ulcerative colitis. We report a case of adrenaleukodystrophy, vitiligo and hypothyroidism.<p class...

Carbimazole is a commonly used antithyroid drug with a rare but potentially life-threatening side effect of agranulocytosis. We present a case of a 47-year-old lady who was diagnosed with hyperthyroidism four years previously and treated with carbimazole despite persistent neutropenia.At diagnosis the patient had clinical features of hyperthyroidism and thyroid function test (TFT) showed free T4 40.8 pmol/l (10.6–21.0), free T3...

Introduction: Weight gain following treatment of hyperthyroidism is well recognised. This may lead to compliance problems both in patients with/without eating disorders and subsequent failure of therapy. We describe two cases where this was successfully managed with supervised in-patient therapy.Case 1: A 30-year-old overweight lady was diagnosed with Grave’s disease following childbirth. Thyroid function test (TFT) at initiation of treatment showed...

Background: Maintenance of euthyroidism is particularly important during pregnancy. In the early stages of gestation, maternal thyroid hormone is required for foetal neurological development. Some authors suggest presumptively increasing the thyroxine replacement at diagnosis of pregnancy. Recent United Kingdom guidelines recommended that thyroid stimulating hormone (TSH) and free T4 (fT4) should be measured in hypothyroid women before conception, at diagnosis of pregnancy, at...

Objective: To define the prevalence of Diabetic Peripheral Neuropathy (DPN), painful diabetic neuropathy (PDN) and the at risk diabetic foot in 2 out of the 3 National Diabetes Centres in Qatar.Methods: 712 people with Type-1 & Type-2 diabetes recruited from Alwakra Hospital and Hamad General Hospital underwent assessment for DPN & PDN using the Neurothesiometer and the DN4 questionnaire, respectively.Results: The average a...

Objective: To assess the impact of launching SKIN (Surface, Keep moving, Incontinence, Nutrition) bundle on development of pressure foot ulcers among in-patients with diabetes.Methods: SKIN Bundle was launched at Dudley Group of Hospitals Foundation Trust in mid- February 2011. Data on pressure foot ulcers were collected among patients with and without diabetes admitted during February 2010– February 2011 and then from February 2011–March 2012,...

Objective: Though many studies have looked at the neonatal outcomes in patients with gestational diabetes on different medications, there is no consensus on the preferred drug for initiation of therapy. We aim to compare the neonatal outcome in a cohort of patients attending our service, to determine if one modality is superior to the other.Methods: This study is a prospective observational study from 1-07-2015 to 31-04-2016. The data of all gestational ...